The Muscle Prof
Phosphatidic Acid (PA) Supplementation
Similarly to HMB, another supplement to consider adding to a supplement stack would be PA. PA regulates many processes within the body, which includes anabolic processes (Wang X et al). In regards to building muscle, activating muscle protein synthesis (MPS) through the stimulation of mTOR may be required (Dibble CC et al). This stimulation can occur through mechanical processes such as lifting weights or nutritional processes such as consuming adequate protein. One study by Mobley et al., found that 1.5g of PA supplementation activated the mTOR pathway.
Joy et al., split 28 male subjects into placebo and PA (750mg daily) during an eight week resistance training program. The results of the study concluded that the PA group increased 1-RM leg press by 52kg (~114lb), increased LBM by 2.4kg (~5.25lb), and decreased body fat by 1.3kg (~3lb), whereas the control group increased 1-RM leg press by 32.5kg (71.5lb), increased LBM by 1.2kg (~2.6lb), and decreased body fat by 0.5kg (~1lb). However recent evidence suggests that PA supplementation alone in older individuals who are not resistance training provides additional no effect on body composition. Here in lies another supplement that will likely only work if your already maximising all the fundamentals.
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