Decreased serum L-arginine and L-citrulline levels in major depression.

#1 von Markus , 29.08.2017 09:40

Die Autoren schlagen vor, dass Depression mit Argininmangel assoziiert sei und daher (indirekt) Depression mit Herz-/Kreislauferkrankungen

Zitat
RATIONALE: It has been suggested that endothelial dysfunction caused by a decreased endothelial production of nitric oxide (NO) may contribute to the consistently observed increased risk of developing cardiovascular disease (CVD) in physically healthy patients suffering from major depression (MD). NO is a gas synthesized from Larginine (a conditionally essential amino acid) and oxygen by endothelial nitric oxide synthase (eNOS). The end products of NO production include both NO and L-citrulline. NO is rapidly reduced to the anions nitrite and nitrate, classically referred to as NO metabolites. Their measurement has been used as a surrogate measurement for endothelial NO production. We and others have shown decreased levels of NO metabolites in the serum of MD patients. The mechanism of this decreased production of NO by the endothelium has not yet been elucidated.

OBJECTIVES: The purpose of this study is to assess serum levels of L-arginine and L-citrulline in patients with MD.

METHODS: Levels of L-arginine and L-citrulline were measured in 35 unmedicated physically healthy MD patients and 36 healthy controls (HCs).

RESULTS: L-arginine and L-citrulline concentrations were significantly lower in MD patients than in healthy controls (L-arginine, 73.54 + 21.53 μmol/L and 84.89 + 25.16, p = 0.04 μmol/L and L-citrulline 31.58 + 6.05 μmol/L and 35.19 + 6.85 μmol/L, p = 0.03, respectively).

CONCLUSIONS: The decrease in L-arginine levels in MD patients is a possible explanation for the decrease in NO metabolites in MD patients and therefore may contribute, through endothelial dysfunction, to the increased CV risk associated with MD.



https://www.ncbi.nlm.nih.gov/m/pubmed/28803324/


Wenn alle "gleich" sein sollen und "gleichgestellt", funktioniert das nur auf dem niedrigsten Niveau. Denn wenn 10 Leute 100m laufen und alle zur gleichen Zeit am Ziel ankommen sollen, dürfen sie alle nur so schnell laufen wie der Langsamste. Nur warum soll der sich dann noch anstrengen, wenn die "Gleichheit" ihn sowieso mit den anderen auf die oberste Stufe des Siegertreppchens stellt? Und was soll das mit der Gesellschaft machen? Kann man sich in jedem (!) sozialistischen Staat anschauen.


 
Markus
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