Prebiotic Reduces Body Fat and Alters Intestinal Microbiota in Children With Overweight or Obesity

#1 von Markus , 10.08.2017 17:30

8 Gramm Inulin am Tag und das Wachstum des Hüftgoldes kehrt sich um. Ebenso wie die Triglyceride und Entzündungsmarker, diese sinken ebenso wie der Darm-pH-Wert (Shift von Bacteroiden hin zu Bifidob.) Klappte hier bei übergewichtigen Kindern.




Zitat
Background & Aims
It might be possible to manipulate the intestinal microbiota with prebiotics or other agents to prevent or treat obesity. However, little is known about the ability of prebiotics to specifically modify gut microbiota in children with overweight/obesity or reduce body weight. We performed a randomized controlled trial to study the effects of prebiotics on body composition, markers of inflammation, bile acids in fecal samples, and composition of the intestinal microbiota in children with overweight or obesity.

Methods
We performed a single-center, double-blind, placebo-controlled trial of 2 separate cohorts (March 2014 and August 2014) at the University of Calgary in Canada. Participants included children, 7–12 years old, with overweight or obesity (>85th percentile of body mass index) but otherwise healthy. Participants were randomly assigned to groups given either oligofructose-enriched inulin (OI; 8 g/day; n=22) or maltodextrin placebo (isocaloric dose, controls; n=20) once daily for 16 weeks. Fat mass and lean mass were measured using dual-energy-x-ray absorptiometry. Height, weight, and waist circumference were measured at baseline and every 4 weeks thereafter. Blood samples were collected at baseline and 16 weeks, and analyzed for lipids, cytokines, lipopolysaccharide, and insulin. Fecal samples were collected at baseline and 16 weeks; bile acids were profiled using high-performance liquid chromatography and the composition of the microbiota was analyzed by 16S rRNA sequencing and quantitative polymerase chain reaction. The primary outcome was change in percent body fat from baseline to 16 weeks.

Results
After 16 weeks, children who consumed OI had significant decreases in body weight z-score (decrease of 3.1%), percent body fat (decrease of 2.4%), and percent trunk fat (decrease of 3.8%) compared with children given placebo (increase of 0.5%, increase of 0.05%, and decrease of 0.3%, respectively). Children who consumed OI also had a significant reduction in level of interleukin 6 from baseline (decrease of 15%) compared with the placebo group (increase of 25%). There was a significant decrease in serum triglycerides (decrease of 19%) in the OI group. Quantitative polymerase chain reaction showed a significant increase in Bifidobacterium spp. in the OI group compared with controls. 16S rRNA sequencing revealed significant increases in species of the genus Bifidobacterium and decreases in Bacteroides vulgatus within the group who consumed OI. In fecal samples, levels of primary bile acids increased in the placebo group but not in the OI group over the 16-week study period.

Conclusions
In a placebo-controlled, randomized trial, we found a prebiotic (OI) to selectively alter the intestinal microbiota and significantly reduce body weight z-score, percent body fat, percent trunk fat, and serum level of interleukin 6 in children with overweight or obesity (Clinicaltrials.gov no: NCT02125955).



http://www.gastrojournal.org/article/S00...5698-6/fulltext
DOI: http://dx.doi.org/10.1053/j.gastro.2017.05.055


«I also think it’s safe to suggest that since our ancestors were undoubtedly active on a regular basis, their robust bone densities indicate a pretty decent physique – unless they somehow found a steady source of fructose-rich honey, continuously gorged on root strips fried in a hollowed-out buffalo skull filled with boiling tallow, and developed an insulin-resistant belly to cover up those muscles.« (Mark Sisson)


 
Markus
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zuletzt bearbeitet 10.08.2017 | Top

RE: Prebiotic Reduces Body Fat and Alters Intestinal Microbiota in Children With Overweight or Obesity

#2 von vera8555 , 11.08.2017 15:42

Da stellt sich mir die Frage, wie das die armen Kínder verdauungstechnisch verkraftet haben.
Schon 6g sind bei mir fast nicht tolerierbar.


vera8555  
vera8555
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RE: Prebiotic Reduces Body Fat and Alters Intestinal Microbiota in Children With Overweight or Obesity

#3 von Markus , 11.08.2017 16:00

Zitat von vera8555 im Beitrag #2
Da stellt sich mir die Frage, wie das die armen Kínder verdauungstechnisch verkraftet haben.



Besser als die Placebogruppe:

Zitat

Side Effects and Compliance
No gastrointestinal side effects were experienced by 70% of participants in the prebiotic group and 61.1% in the placebo. A mild increase in flatulence and bloating was experienced by 25% and 27.8% of subjects in prebiotic and placebo, respectively. A moderate increase in flatulence and bloating was reported by 5% and 11.1% of subjects in prebiotic and placebo, respectively. During the informal interview to assess blinding, 50% of the prebiotic group and 72.2% of the placebo group were able to correctly guess their grouping. There was 87% and 91% compliance in the prebiotics and placebo group, respectively.


«I also think it’s safe to suggest that since our ancestors were undoubtedly active on a regular basis, their robust bone densities indicate a pretty decent physique – unless they somehow found a steady source of fructose-rich honey, continuously gorged on root strips fried in a hollowed-out buffalo skull filled with boiling tallow, and developed an insulin-resistant belly to cover up those muscles.« (Mark Sisson)


 
Markus
Beiträge: 2.717
Registriert am: 28.05.2014


   

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