Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet

#1 von Markus , 31.10.2016 10:41

Prä-Diabetes wurde nach 6 Minuten mit High Protein (30%) geheilt. Die High Carb-Fraktion hingegen (in etwa die DGE-Empfehlung von den Makros her) schnitt dagegen schlecht ab.


Zitat
Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet: randomized control trial


Abstract
Objective Remission of pre-diabetes to normal is an important health concern which has had little success in the past. This study objective was to determine the effect on remission of pre-diabetes with a high protein (HP) versus high carbohydrate (HC) diet and effects on metabolic parameters, lean and fat body mass in prediabetic, obese subjects after 6 months of dietary intervention.

Research design and methods We recruited and randomized 24 pre-diabetes women and men to either a HP (30% protein, 30% fat, 40% carbohydrate; n=12) or HC (15% protein, 30% fat, 55% carbohydrate; n=12) diet feeding study for 6 months in this randomized controlled trial. All meals were provided to subjects for 6 months with daily food menus for HP or HC compliance with weekly food pick-up and weight measurements. At baseline and after 6 months on the respective diets oral glucose tolerance and meal tolerance tests were performed with glucose and insulin measurements and dual energy X-ray absorptiometry scans.

Results After 6 months on the HP diet, 100% of the subjects had remission of their pre-diabetes to normal glucose tolerance, whereas only 33.3% of subjects on the HC diet had remission of their pre-diabetes. The HP diet group exhibited significant improvement in (1) insulin sensitivity (p=0.001), (2) cardiovascular risk factors (p=0.04), (3) inflammatory cytokines (p=0.001), (4) oxidative stress (p=0.001), (5) increased percent lean body mass (p=0.001) compared with the HC diet at 6 months.

Conclusions This is the first dietary intervention feeding study, to the best of our knowledge, to report 100% remission of pre-diabetes with a HP diet and significant improvement in metabolic parameters and anti-inflammatory effects compared with a HC diet at 6 months.



http://drc.bmj.com/content/4/1/e000258


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Markus
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RE: Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet

#2 von Chris (edubily) , 31.10.2016 11:19

Das ist eine wirklich interessante Studie, die werde ich mal in einen Artikel packen.

Bemerkenswert ist ja auch, dass die "HP"-Gruppe Magermasse gewonnen hat.

Dass die DGE-Empfehlungen für den A... sind, das dürfte mittlerweile eh jedem klar sein. Aber ich befürchte, dass ich in den nächsten Tagen irgendwo im Internet lesen: "40 % statt 55 % Carbs ist ja gut und schön. Was wäre, würde man 10 % Carbs essen?" Ich bin mir ziemlich sicher, dass das wiederum schlechter wäre für die glykämische Kontrolle etc. Gibt dazu schöne Studie, die beschrieben haben, dass physiologische Insulinresistenz sogar bei hypokalorischen Ernährungsformen deutlich zum Tragen kommt.

40:30:30 klingt für mich bisher a) am Machbarsten und b) am Sinnvollsten (mit Blick auf IR und Co.)


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Chris (edubily)
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