Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms

#1 von Markus , 23.09.2016 10:33

Zitat
Abstract

In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and ‘heme A’, and thereby ATP generation. Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification. Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress. An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency. Thus, the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs. We propose that current statin treatment guidelines be critically reevaluated.

Keywords: atherosclerosis, ATP generation, coenzyme Q10, heart failure, mitochondrial toxin, selenoprotein, statin, statin cardiomyopathy, vitamin K2,



http://www.tandfonline.com/doi/full/10.1...33.2015.1011125


"Wer sich stets viel geschont hat, der kränkelt zuletzt an seiner vielen Schonung. Gelobt sei, was hart macht.“
(Friedrich Nietzsche)


 
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RE: Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms

#2 von Markus , 23.09.2016 10:41

Also Selenenzyme und Q10

Passend dazu aus dem aktuellen Mitgliederheft der Life Extension Foundation: Selen in Kombination mit Q10 senkt das Herzsterblichkeitsrisiko. Deutlich!

Selen und Q10 sind also "Herzschutzmittel". Statine dagegen zerstören Selenoproteine und stören die Q10- und K2-Synthese und wirken somit über diese Pfade langfristig gegen die Herzkreislauf-Gesundheit- während sie gleichzeitig die Partikelzahl an Lipoproteinen und damit zusätzliche Artherioskleroseprozeße zu senken vermögen. Es dürfte eine Frage des persönlichen Stoffwechsels, der Risikolage und der "Stofflage" (Versorgung) sein, die darüber entscheidet, in welche Richtung die Waage bei Statineinnahme kippt. Immer weniger aber die einer abstrakten Zahl namens "Gesamtcholesterin" aufgrund derer der Rezeptblock meist gezückt wird.

Ausnahme: Sekundärprophylaxe, also nach einem Infarkt. Hier schaut die Datenlage positiv zugunsten einer Verschreibung aus.


Zitat
CoQ10 and selenium are both involved in the management of cellular energy. Each compound works to influence energy production and utilization of this energy by organs throughout the body.8 Studies now show that CoQ10 and selenium have effects that help protect against tissue-damaging oxidative stress.8-10

Researchers from Sweden conducted a double-blind, placebo-controlled study that included 443 healthy adults between 70 and 88 years old.1 The participants received either a placebo or a combination of 200 mg a day of CoQ10 and 200 mcg a day of selenium tablets.

During an extensive follow up time of 5.2 years, 12.6% of the placebo recipients had died of cardiovascular disease, compared to only 5.9% in the supplement group, which is an impressive and significant difference.1

Those taking the combination of CoQ10 and selenium also had significantly better scores on cardiac function compared to those taking the placebo, as determined by an echocardiogram. In addition, levels of a biomarker for heart failure called NT-proBNP (“N-terminal pro-brain natriuretic protein”) were significantly reduced,1 which is a favorable finding that indicates reduced cardiovascular disease risk.11
...
For this follow-up analysis from the initial Swedish study, when subjects were matched by age, gender, and baseline heart function, the difference was clear. While quality of life scores declined in all subjects (as it does in so many people as they age), the decline was significantly less sharp in the supplemented CoQ10/selenium group than in the placebo group.3

In addition, over the 4-year period, the people in the supplemented group spent 246 fewer days in the hospital than those in the placebo group.
...
A further analysis from the initial Swedish study reveals perhaps the most surprising finding from this major study which was that CoQ10 and selenium were still effective at reducing cardiovascular deaths 10 years after the start of the study.4 This means that CoQ10 and selenium continued to extend their life-saving benefits years after the participants stopped taking the supplements!

At the ten-year mark, the risk of dying from any cardiovascular cause (heart attack, stroke, congestive heart failure, and others) was 49% lower in those who had originally received supplementation, compared with those who had not.4 This effect was evenly divided across the various forms of heart disease, including ischemic heart disease and in those with diabetes. Both men and women in the study experienced the same degree of protection.


http://www.lifeextension.com/Magazine/20...rtality/Page-01


"Wer sich stets viel geschont hat, der kränkelt zuletzt an seiner vielen Schonung. Gelobt sei, was hart macht.“
(Friedrich Nietzsche)


 
Markus
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RE: Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms

#3 von naklar! , 23.09.2016 12:12

Danke Markus, das ist für mich - familiär - sehr wichtig!

Eric


" Ich will mehr Leben, Vater! "


 
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RE: Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms

#4 von wmuees , 23.09.2016 12:46

Habe noch eine ungeöffnete Packung Statine im Schrank ... mein Arzt wollte mich auch damit beglücken.
Statt dessen bin ich mit Q10, Vitamin K2 und Selen (im 2perDay) ganz gut unterwegs.

Die Statine habe ich damals abgelehnt, weil die Cochrane-Metastudie zum Thema "nützen Statine bei leichtem Bluthochdruck etwas" ein klares "Nein" als Ergebnis brachte.


 
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RE: Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms

#5 von Markus , 26.09.2016 13:23

Irgendwie passend dazu dieses Editorial des British Medical Journal (eines sehr häufig zitierten Blattes):

Statins: we need an independent review

http://www.bmj.com/content/354/bmj.i4992


"Wer sich stets viel geschont hat, der kränkelt zuletzt an seiner vielen Schonung. Gelobt sei, was hart macht.“
(Friedrich Nietzsche)


 
Markus
Beiträge: 2.735
Registriert am: 28.05.2014


   

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