Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism.

#1 von Markus , 21.07.2016 14:08

Sellerie als Fasten- bzw. CR-Mimetikum? Zumindest in Mäusen bei deren Fettzellen!



Zitat
Int J Obes (Lond). 2016 Jul 5. doi: 10.1038/ijo.2016.108. [Epub ahead of print]
Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism.
Zhang X1, Zhang QX1, Wang X1, Zhang L1, Qu W1, Bao B1, Liu CA1, Liu J1.
Author information

Abstract
BACKGROUND:
Two brown-like adipocytes, including classical brown adipocytes from brown adipose tissues and beige cells from white adipose tissues, regulate thermogenesis. The developmental and functional induction of brown-like cells provides a defense against obesity and associated metabolic diseases. Our previous study suggests dietary luteolin can improve diet-induced obesity and insulin resistance in mice. Here we further elucidated the action of the natural flavonoid on energy expenditure and adaptive thermogenesis.
METHODS:
Five-week-old male C57BL/6 mice were fed low-fat diet (LFD), high-fat diet (HFD) and HFD supplemented with 0.01% luteolin. After 12 weeks, their energy expenditure were detected using a combined indirect calorimetry system. Moreover, thermogenic program and associated molecular regulators were assessed in adipose tissues. In another independent study, even-aged mice were fed LFD and luteolin-containing LFD for 12 weeks, and their energy expenditure and thermogenic program were also investigated. Finally, differentiated primary brown and subcutaneous adipocytes were used to identify the critical participation of AMPK/PGC1α signaling in luteolin-regulated browning and thermogenesis.
RESULTS:
In mice fed either HFD or LFD, dietary luteolin supplement increased oxygen consumption, carbon dioxide production and respiratory exchange ratio. The enhancement in energy expenditure was accompanied by the upregulation of thermogenic genes in brown and subcutaneous adipose tissues. Meanwhile, several important AMPK/PGC1α signaling molecules were activated by dietary luteolin in the tissues. Further, luteolin treatment directly elevated thermogenic gene expressions and activated AMPK/PGC1α signaling in differentiated primary brown and subcutaneous adipocytes, whereas AMPK inhibitor Compound C reversed the efficiencies.

CONCLUSIONS:
Dietary luteolin activated browning and thermogenesis through an AMPK/PGC1α pathway-mediated mechanism.International Journal of Obesity advance online publication, 5 July 2016; doi:10.1038/ijo.2016.108.


http://www.ncbi.nlm.nih.gov/pubmed/27377953

Ach ja, 0,01% entsprechen rund 100 mg beim Menschen. Und Sellerie hat etwa 200 mg Luteolin/ kg Frischgewicht. Von Swanson gibt es auch Kapseln mit 100 mg.


"Probleme, die geleugnet werden, müssen auch nicht gelöst werden. Offiziell nennt man das dann "political corrrectness"...
(Hendryk M. Broder)


 
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