Bergamot ist eine Zitronen-Hybride, die vor allem auf Sizilien kultiviert wird und dessen Saft (nicht aber das häufig anzutreffende Kern-Öl) eine einzgartige Polyphenol-Zusammensetzung aufweist, die den AMPK-Pfad aktiviert. Ideal bei "Diabesity", also metabolischem Syndrom:
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders.
Zu dieser Studie finde ich folgende Ergebnisse:
In 2011, Italian researchers tested the effects of bergamot extract on 237 patients with abnormal cholesterol with diet-induced hyperlipidemia. Published in the peer-reviewed journal Fitoterapia, the research demonstrated stunningly beneficial effects on blood fats and blood sugar. Study subjects show an average 30 percent reduction in total cholesterol, a 38 percent reduction in LDL (bad) cholesterol, a 40 percent increase in HDL (good) cholesterol, an up to 40 percent drop in triglycerides, and a 20 percent drop in blood sugar.
In another study, researchers found that bergamot extract improved the function of the endothelium, which is the single layer of cells that lines every blood vessel in the body.
Also 20% beim Blutzucker sind schom eine Welt...dazu die Tris und LDL um mehr als ein 1/3 reduziert....und eine endotheliale Dysfunktion entschärft!
Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia.
Statins are the most commonly prescribed drugs to reduce cardiometabolic risk. Besides the well-known efficacy of such compounds in both preventing and treating cardiometabolic disorders, some patients experience statin-induced side effects. We hypothesize that the use of natural bergamot-derived polyphenols may allow patients undergoing statin treatment to reduce effective doses while achieving target lipid values. The aim of the present study is to investigate the occurrence of an enhanced effect of bergamot-derived polyphenolic fraction (BPF) on rosuvastatin-induced hypolipidemic and vasoprotective response in patients with mixed hyperlipidemia.
A prospective, open-label, parallel group, placebo-controlled study on 77 patients with elevated serum LDL-C and triglycerides was designed. Patients were randomly assigned to a control group receiving placebo (n=15), two groups receiving orally administered rosuvastatin (10 and 20mg/daily for 30 days; n=16 for each group), a group receiving BPF alone orally (1000 mg/daily for 30 days; n=15) and a group receiving BPF (1000 mg/daily given orally) plus rosuvastatin (10mg/daily for 30 days; n=15).
Both doses of rosuvastatin and BPF reduced total cholesterol, LDL-C, the LDL-C/HDL-C ratio and urinary mevalonate in hyperlipidemic patients, compared to control group. The cholesterol lowering effect was accompanied by reductions of malondialdehyde, oxyLDL receptor LOX-1 and phosphoPKB, which are all biomarkers of oxidative vascular damage, in peripheral polymorphonuclear cells.
Addition of BPF to rosuvastatin significantly enhanced rosuvastatin-induced effect on serum lipemic profile compared to rosuvastatin alone. This lipid-lowering effect was associated with significant reductions of biomarkers used for detecting oxidative vascular damage, suggesting a multi-action enhanced potential for BPF in patients on statin therapy.
Wer's braucht bzw. ausprobieren möchte, ich habe zwei Präparate gefunden: Bergamet Mega und "Bergamot Citrus" von Jarrow..