Eine Ernährung mit niedrigem Anteil an Ballaststoffen, wie sie im Westen und bei manchen Ketariern üblich geworden ist- führt zu einer Verarmung der Vielfalt der Darmflora. Das ist bekannt. Neu ist, dass diese Verarmung auch an die Kinder weitergegeben wird. Und zwar irreversibel! Epigenetische Änderungen können also wieder durch Lifestyleänderungen der Kinder reversibel gemacht werden, Biomänderungen aber nicht mehr- ein echter Treppenwitz! EInziger Ausweg: die Fekaltransplantation ("poop pill")- da werden wir in den nächsten Jahren noch sehr viel von hören, jede Wette...
When mice with gut bacteria from a human were put on a low-fiber diet, the diversity of their intestinal inhabitants plummeted. Four generations on a low-fiber diet caused irreversible losses.
A study by Stanford University School of Medicine investigators raises concerns that the lower-fiber diets typical in industrialized societies may produce internal deficiencies that get passed along to future generations.
The study, conducted in mice, indicates that low-fiber diets not only deplete the complex microbial ecosystems residing in every mammalian gut, but can cause an irreversible loss of diversity within those ecosystems in as few as three or four generations.
Once an entire population has experienced the extinction of key bacterial species, simply “eating right” may no longer be enough to restore these lost species to the guts of individuals in that population, the study suggests. Those of us who live in advanced industrial societies may already be heading down that path.
The proliferation of nearly fiber-free, processed convenience foods since the mid-20th century has resulted in average per capita fiber consumption in industrialized societies of about 15 grams per day. That’s as little as one-tenth of the intake among the world’s dwindling hunter-gatherer and rural agrarian populations, whose living conditions and dietary intake presumably most closely resemble those of our common human ancestors, said Justin Sonnenburg, PhD, associate professor of microbiology and immunology and senior author of the study, published Jan. 13 in Nature.....
The real surprise came after mice had been bred and maintained on low-fiber diets for a few generations. In their experimental confines, these mice were exposed to microbes only through contact with their parents. Each successive generation’s gut-bacterial ecosystem declined in diversity. By generation four, the depletion had reached a point where nearly three-quarters of the bacterial species resident in their great-grandparents’ guts appeared absent in their own. Even after these mice were put back on a high-fiber diet, more than two-thirds of the bacterial species identified in the guts of their first-generation ancestors proved irretrievable, indicating extinction of those species by the fourth generation of fiber deprivation.
On the other hand, a somewhat more aggressive measure — fecal transplantation — did result in these lost species’ retrieval, the study found