Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism

#1 von Markus , 27.01.2016 11:58

IDO (Indoleamine-2,3-dioxygenase) wird durch Entzündungsmarker hochreguliert und dadurch wird vermehrt Tryptophan in Kynurenin abgebaut. Ähnliches gilt für guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1), das Tyrosin und Phenylalanin zu Biopterin abbaut. Damit fehlt durch Entzündungen also tendeziell sowohl Tryptophan für den Stoffwechselpfad, der zu Serotinin/Melatonin führt wie auch Tyrosin und Phenylalanin für die Dopamin-Produktion.

Also anstatt sich der lieben Neurotransmitter wegen pfundweise mit Tyrosin und Tryptophan zuzuschütten (=Zufluß) könnte man sich vielleicht auch mal um seine Entzündungsmarker (wie etwa CRP, IL-6) kümmern und damit den Abfluß stoppen. Oder wenigstens diese beiden "Abfluß-"Enzyme hemmen, etwa mit Resveratrol*, EGCG, Vitamin B3, C und E.


* http://www.ncbi.nlm.nih.gov/pubmed/16154495

Zitat

Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms.
Capuron L1, Schroecksnadel S, Féart C, Aubert A, Higueret D, Barberger-Gateau P, Layé S, Fuchs D.


Abstract
BACKGROUND:
Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of aging, plays a role. Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines. The present study assessed this possibility in 284 healthy elderly subjects drawn from the Three-City cohort.
METHODS:
Assays included the measurement of serum interleukin-6 and C-reactive-protein, as inflammatory markers; tryptophan, kynurenine, and their ratio as index of IDO activity; and neopterin, phenylalanine, tyrosine, and nitrite, as markers of GTP-CH1 activity. In addition, structured assessments of depressive symptomatology, fatigue, and general behavioral/neurovegetative symptoms were performed.
RESULTS:
As expected, age correlated significantly with concentrations of immune markers and neuropsychiatric symptoms. Increased inflammation was related to reduced tryptophan concentrations and increased kynurenine levels, suggestive of IDO-induced increased tryptophan catabolism. In addition, inflammation was associated with increases in neopterin and nitrite levels and in phenylalanine concentrations at the expense of tyrosine. Interestingly, increased tryptophan catabolism was associated with the depressive symptoms of lassitude, reduced motivation, anorexia, and pessimism. In contrast, variations in markers of GTP-CH1 activity correlated more with neurovegetative symptoms, including sleep disturbance, digestive symptoms, fatigue, sickness, and motor symptoms.
CONCLUSIONS:
These findings show that chronic low-grade inflammation in aging is associated with alterations in enzymatic pathways involved in monoamine metabolism and suggest that these alterations might participate in the pathophysiology of neuropsychiatric symptoms in elderly persons.


http://www.ncbi.nlm.nih.gov/pubmed/21277567


"Toleranz wird zum Verbrechen, wenn sie dem Bösen gilt." (Thomas Mann, "Der Zauberberg")


 
Markus
Beiträge: 2.729
Registriert am: 28.05.2014

zuletzt bearbeitet 27.01.2016 | Top

   

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation.
Insulin beeinflusst Dopamin-Level

disconnected Foren-Chat Mitglieder Online 8
Xobor Einfach ein eigenes Forum erstellen