Physical exercise increases autophagic signaling through ULK1 in human skeletal muscle

#1 von Markus , 26.08.2015 09:17

Egal, ob du vorher tüchtig Carbs gegessen oder 36h gefastet hattest: 60 Minuten Sport- und Autophagie und AMPK sind aktiviert:

Abstract

Zitat

Data from transgenic animal models suggest that exercise-induced autophagy is critical for adaptation to physical training, and that Unc-51 like kinase-1 (ULK1) serves as an important regulator of autophagy. Phosphorylation of ULK1 at Ser555 stimulates autophagy, whereas phosphorylation at Ser757 is inhibitory. To determine whether exercise regulates ULK1 phosphorylation in humans in vivo in a nutrient-dependent manner, we examined skeletal muscle biopsies from healthy humans after 1-h cycling exercise at 50% maximal O2 uptake on two occasions: 1) during a 36-h fast, and 2) during continuous glucose infusion at 0.2 kg/h. Physical exercise increased ULK1 phosphorylation at Ser555 and decreased lipidation of light chain 3B. ULK1 phosphorylation at Ser555 correlated positively with AMP-activated protein kinase-α Thr172 phosphorylation and negatively with light chain 3B lipidation. ULK1 phosphorylation at Ser757 was not affected by exercise. Fasting increased ULK1 and p62 protein expression, but did not affect exercise-induced ULK1 phosphorylation. These data demonstrate that autophagy signaling is activated in human skeletal muscle after 60 min of exercise, independently of nutritional status, and suggest that initiation of autophagy constitutes an important physiological response to exercise in humans.



http://jap.physiology.org/content/118/8/971


„Wenn man sich die Methoden betrachtet mit denen die Pharmaindustrie die Entscheidungsträger unter Druck setzt, so gehören die eigentlich in die mafiösen Strukturen.“
Uwe Dolata (Kriminalhauptkommissar) in "Das Pharmakartell: Wie wir als Patienten betrogen werden", Frontal21, 2008.


 
Markus
Beiträge: 2.729
Registriert am: 28.05.2014


RE: Physical exercise increases autophagic signaling through ULK1 in human skeletal muscle

#2 von lazy , 26.08.2015 18:13

ich finde, hier fehlt noch sowas wie ein like-button im forum :)


lazy  
lazy
Beiträge: 24
Registriert am: 21.02.2015


RE: Physical exercise increases autophagic signaling through ULK1 in human skeletal muscle

#3 von Luna , 26.08.2015 21:54

Stimmt!


 
Luna
Beiträge: 622
Registriert am: 28.05.2014


   

Warum Citrullin Arteriosklerose verhindert
Increased Lean Red Meat Intake Does Not Elevate Markers of Oxidative Stress and Inflammation in Humans

disconnected Foren-Chat Mitglieder Online 6
Xobor Einfach ein eigenes Forum erstellen